CANNABIS SATIVA

Cannabis sativa

Cannabis sativa is an annual herbaceous plant in the Cannabaceae family. Humans have cultivated this herb throughout recorded history as a source of industrial fibre, seed oil, food, recreation, spiritual enlightenment and medicine. Each part of the plant is harvested differently, depending on the purpose of its use.

Common uses

Its seed, chiefly used as caged-bird feed, is a valuable source of protein. The flowers (and to a lesser extent the leaves, stems, and seeds) contain psychoactive and physiologically active chemical compounds known as cannabinoids that are consumed for recreational, medicinal, and spiritual purposes. When so used, preparations of flowers (marijuana) and leaves and preparations derived from resinous extract (hashish) are consumed by smoking, vaporizing and oral ingestion. Historically, tinctures, teas, and ointments have also been common preparations.

Plant physiology

The flowers of the female plant are arranged in racemes and can produce hundreds of seeds. Male plants shed their pollen and die several weeks prior to seed ripening on the female plants. Although genetic factors dispose a plant to become male or female, environmental factors including the diurnal light cycle can alter sexual expression.^{[citation needed]} Naturally occurring monoecious plants, with both male and female parts, are either sterile or fertile but artificially induced "hermaphrodites" (a commonly used misnomer) can have fully functional reproductive organs. "Feminized" seed sold by many commercial seed suppliers are derived from artificially "hermaphrodytic" females that lack the male gene, or by treating the seeds with hormones or silver thiosulfate.

A Cannabis plant in the vegetative growth phase of its life requires more than 12–13 hours of light per day to stay vegetative. Flowering usually occurs when darkness equals at least 12 hours per day. The flowering cycle can last anywhere between nine to fifteen weeks, depending on the strain and environmental conditions.In soil, the optimum pH for the plant is 6.3 to 6.8. In hydroponic growing, the nutrient solution is best at 5.2 to 5.8, making Cannabis well-suited to hydroponics because this pH range is hostile to most bacteria and fungi.

·         Cultivars primarily cultivated for their fiber, characterized by long stems and little branching.

·         Cultivars grown for seed from which hemp oil is extracted.

·         Cultivars grown for medicinal or recreational purposes. A nominal if not legal distinction is often made between industrial hemp, with concentrations of psychoactive compounds far too low to be useful for that purpose, and it is also known as marijuana.

·         Pharmacology

Although the main psychoactive chemical compound in Cannabis is Δ⁹-tetrahydrocannabinol (THC), the plant is known to contain about sixty cannabinoids; however, most of these "minor" cannabinoids are only produced in trace amounts. Besides THC, another cannabinoid produced in high concentrations by some plants is cannabidiol (CBD), which is not psychoactive but has recently been shown to block the effect of THC in the nervous system.^[1] Differences in the chemical composition of Cannabis varieties may produce different effects in humans. Synthetic THC, called dronabinol, does not contain CBD, CBN, or other cannabinoids, which is one reason why its pharmacological effects may differ significantly from those of natural Cannabis preparations.

Chemical constituents

Cannabis chemical constituents including about 100 compounds responsible for its characteristic aroma. These are mainly volatile terpenes and sesquiterpenes.

·         Δ⁹-Tetrahydrocannabinol

·         α-Pinene^[2]

·         Myrcene^[2]

·         Trans-β-ocimene^[2]

·         α-Terpinolene^[2]

·         Trans-caryophyllene^[2]

·         α-Humulene,^[2] contributes to the characteristic aroma of Cannabis sativa

·         Caryophyllene-oxide,^[2] with which some hashish detection dogs are trained^[3]

Medical use

Cannabis used medically has several well-documented beneficial effects. Among these are: the amelioration of nausea and vomiting, stimulation of hunger in chemotherapy and AIDS patients, lowered intraocular eye pressure (shown to be effective for treating glaucoma), as well as general analgesic effects (pain reliever).b[›] Less confirmed individual studies also have been conducted indicating cannabis to be beneficial to a gamut of conditions running from multiple sclerosis to depression. Synthesized cannabinoids are also sold as prescription drugs, including Marinol (dronabinol in the United States and Germany) and Cesamet (nabilone in Canada, Mexico, the United States and the United Kingdom).b[›]

Currently, the U.S. Food and Drug Administration (FDA) has not approved smoked cannabis for any condition or disease in the United States, largely because good quality scientific evidence for its use from U.S. studies is lacking.[18] Regardless, fourteen states have legalized cannabis for medical use.[19][20] The United States Supreme Court has ruled in United States v. Oakland Cannabis Buyers' Coop and Gonzales v. Raich that it is the federal government that has the right to regulate and criminalize cannabis, even for medical purposes. Canada, Spain, The Netherlands and Austria have legalized some form of cannabis for medicinal use.

Long-term effects

Cannabis is ranked one of the least harmful drugs by a study published in the UK medical journal, The Lancet.  Given the limitations of the research, scientists still debate the possibility of cannabis dependence; the potential of cannabis as a "gateway drug"; its effects on intelligence and memory; its effect on the lungs; and the relationship, if any, of cannabis use to mental disorders[23] such as schizophrenia,[24] psychosis,[25] Depersonalization disorder[26] and depression.[27]